Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease.

Aims of the study: Patient comprehension is a critical part of meeting medical ethics standards of informed consent in study designs. The aim of the study was to determine if sufficient literature exists to require clinicians to disclose the specific risk that COVID-19 vaccines could worsen disease upon exposure to challenge or circulating virus. Results […]

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SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Vascular endothelium can be infected by SARS-CoV-2, which triggers mitochondrial reactive oxygen species production and glycolytic shift. Paradoxically, ACE2 is protective in the cardiovascular system, and SARS-CoV-1 S protein […]

Read More SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2

Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease

Abstract Aims of the study: Patient comprehension is a critical part of meeting medical ethics standards of informed consent in study designs. The aim of the study was to determine if sufficient literature exists to require clinicians to disclose the specific risk that COVID-19 vaccines could worsen disease upon exposure to challenge or circulating virus. […]

Read More Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease